S23 Powder | 2 Grams

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S23 Powder — 2 Grams

S23, also designated S-23, is a non-steroidal selective androgen receptor modulator (SARM) of
the aryl-propionamide class, developed in academic research at the University of Tennessee. This listing is a
research-grade reference compound supplied in powder form for in vitro and
laboratory investigation. Identity and purity are third-party verified and documented by a downloadable
Certificate of Analysis.

• 99.8% purity (HPLC)
• Third-party verified
• 2,050 mg net
• Public COA
• UV-resistant foil pouch

Research Context

S23 was developed and characterized by the University of Tennessee research group responsible for several early
aryl-propionamide SARMs.^[4] Its preclinical characterization in rats evaluated high-affinity androgen
receptor binding, tissue selectivity, and its potential as a component of hormonal male contraception, including
the reversibility of its effects on spermatogenesis.^[1] Later rat studies examined it in models of
glucocorticoid- and hypogonadism-induced muscle atrophy^[2] and of sexual motivation in ovariectomized
female rats.^[3] S23 has not been evaluated in published human clinical trials, and its safety profile
in humans is unknown.

This material is supplied strictly as a reference compound to support such laboratory investigation. It is
not a therapeutic product, dietary supplement, or sports supplement, and no clinical or
performance outcomes are claimed or implied for any individual.

Scientific References

1. Jones A, Chen J, Hwang DJ, Miller DD, Dalton JT. Preclinical characterization of a (S)-N-(4-cyano-3-trifluoromethyl-phenyl)-3-(3-fluoro, 4-chlorophenoxy)-2-hydroxy-2-methyl-propanamide: a selective androgen receptor modulator for hormonal male contraception. Endocrinology. 2009;150(1):385–395.
2. Jones A, Hwang DJ, Narayanan R, Miller DD, Dalton JT. Effects of a novel selective androgen receptor modulator on dexamethasone-induced and hypogonadism-induced muscle atrophy. Endocrinology. 2010;151(8):3706–3719.
3. Jones A, Hwang DJ, Duke CB 3rd, et al. Nonsteroidal selective androgen receptor modulators enhance female sexual motivation. J Pharmacol Exp Ther. 2010;334(2):439–448.
4. Narayanan R, Mohler ML, Bohl CE, Miller DD, Dalton JT. Selective androgen receptor modulators in preclinical and clinical development. Nucl Recept Signal. 2008;6:e010.
5. Van Wagoner RM, Eichner A, Bhasin S, Deuster PA, Eichner D. Chemical Composition and Labeling of Substances Marketed as Selective Androgen Receptor Modulators and Sold via the Internet. JAMA. 2017;318(20):2004–2010.
6. World Anti-Doping Agency. The Prohibited List, Section S1.2: Other Anabolic Agents. WADA.org.