HCG 5000 IU

hCG is a complex glycoprotein hormone, so it behaves differently from synthetic peptides like BPC-157 or Ipamorelin during HPLC testing. Its structure can produce multiple peaks, making a single purity percentage inaccurate.

Instead, its quality is assessed through identity and hormone content, which are more meaningful measures for this product.

IU measures biological activity, while independent laboratory testing measures the amount of hormone by weight. Direct activity testing requires specialized bioassays that are not typically available through independent laboratories.

For hCG, the measured weight is converted to IU using the WHO reference standard. This is a calculated value, not a direct activity measurement, so it may differ from the labeled IU.

In short, these lab reports measure hormone identity and content, not biological potency. Differences from the labeled IU do not necessarily indicate a problem with the batch.

hCG and LH share the same receptor (LHCGR) but have significantly different half-lives. hCG's heavily sialylated β-subunit extends its plasma half-life to approximately 24–36 hours versus LH's 20–60 minutes. This makes hCG the preferred tool in preclinical models requiring sustained LHCGR stimulation rather than pulsatile receptor engagement.

LHCGR is a Gsα-coupled GPCR. Ligand binding activates adenylyl cyclase, elevating intracellular cAMP and triggering PKA-mediated phosphorylation of downstream steroidogenic targets including CYP11A1, CYP17A1, and 3β-HSD. Parallel Gq/11-mediated IP3/DAG signalling has also been documented in some cell models.

HCG 5000 IU lyophilisate is reconstituted with bacteriostatic water (BAC water) for laboratory use. The vial should be gently swirled — not vortexed — until fully dissolved. Reconstituted solution should be stored at 4°C and used within laboratory-established stability windows.